The Rule of Two
Individuals who have the following are more likely to have mutations in BRCA1 or BRCa2:
Two or more family members with breast and/or ovarian cancer.
A family history of breast or ovarian cancer over two generations, on the same side of the family (mother or father’s side).
Family members diagnosed with breast cancer at an early age (especially age 45 and younger).
A history of both breast and ovarian cancer in the family. Or a family member with more than one cancer, such as cancer in both breasts or breast and ovarian cancer together.
A male family member with breast cancer. Breast cancer occurs in about one in 1,000 men.